Troponin I showed no association with COPD in individuals without cardiovascular disease (adjusted OR 0.87, 95% CI 0.60-1.26), meaning elevations require cardiovascular evaluation.
Is elevated Troponin I associated with COPD in individuals without cardiovascular disease?
Troponin I elevations in patients with mild to moderate COPD are not driven by pulmonary disease itself and should prompt a cardiovascular evaluation.
Absolute Event Rate: 0% vs 0%
Elevated troponin I (TnI) has been reported in patients with chronic obstructive pulmonary disease (COPD) without cardiovascular disease (CVD), suggesting non-ischaemic mechanisms. We assessed this association in a population-based cohort of 22 526 individuals without known CVD or significant coronary artery calcification. TnI showed no association with COPD (adjusted OR 0.87, 95% CI 0.60 to 1.26; highest category vs below limit of detection) or with forced expiratory volume in 1 s/forced vital capacity (adjusted difference 0.002, 95% CI −0.001 to 0.004). Median TnI was 2.2 ng/L in both obstructive and non-obstructive groups. These findings do not support a pulmonary source of TnI elevation in mild to moderate, stable COPD and suggest that TnI elevations should prompt cardiovascular evaluation rather than being attributed to pulmonary disease alone.
Ström et al. (Fri,) reported a other. Troponin I showed no association with COPD in individuals without cardiovascular disease (adjusted OR 0.87, 95% CI 0.60-1.26), meaning elevations require cardiovascular evaluation.