Key result
Rare GOLGA4::PDGFRB rearrangement presents as persistent hypereosinophilia in only the second reported pediatric case.
Why the study?
Myeloid/lymphoid neoplasms with eosinophilia are rare in childhood with limited case reports, presenting diagnostic, treatment, and follow-up challenges amid a lack of pediatric guidelines.
Highlights the diagnostic and therapeutic challenges of a rare GOLGA4::PDGFRB rearrangement in pediatric myeloid/lymphoid neoplasms with eosinophilia.
Answers are grounded in this paper and cite their sources.
Warrants molecular testing in infantile hypereosinophilia to detect targetable fusions; extends sparse pediatric experience with GOLGA4::PDGFRB rearrangement.
Myeloid/lymphoid neoplasms with eosinophilia (MLN-eos) are rare hematological malignancies in childhood and limited to isolated case reports in the literature. We discuss the case of an infant who was evaluated for persistent hypereosinophilia and diagnosed with a rare genetic rearrangement; GOLGA4::PDGFRB was previously reported only once in a 13-month-old boy. A literature review of all children with PDGFRB rearrangement was collated in our analysis. The challenges of diagnosis, treatment, and follow-up posed by such a rare genetic disorder with no pediatric guidelines are being discussed.
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Krishnan et al. (2026) studied this question. An infant with persistent hypereosinophilia was diagnosed with a rare GOLGA4::PDGFRB rearrangement, representing only the second reported pediatric case of this specific genetic disorder.
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