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March 29, 2026Journal of Bioresources and Bioproducts0 citationsOpen Access

Elucidating Surfactants That Alleviate Phenolic Inhibition in Lignocellulose Hydrolysis

Rational Screening and Mechanistic Elucidation of Surfactants for Mitigating Phenolic Inhibition in Lignocellulose Enzymatic Hydrolysis: Combining Experimental and Computational Approaches

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Authors

XJXiaoxiao JiangZWZ. WangYWYujie Wang

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Overview

Experimental and computational analyses reveal surfactants mitigate enzyme inhibition by phenolic compounds, suggesting new approaches for enzymatic hydrolysis.

Key Points

  • This study aims to investigate how different surfactants can reduce the inhibition of enzymes by phenolic compounds during lignocellulose hydrolysis.
  • Quantitative characterization of various surfactants' effects on enzyme inhibition.
  • Experimental analysis to assess surfactants' capability to mitigate enzyme deactivation and precipitation.
  • Circular dichroism spectroscopy to evaluate changes in enzyme structure.
  • Molecular docking simulations to determine binding affinities of surfactants to cellulase.
  • Surfactants significantly reduced phenolic-induced enzyme deactivation and precipitation.
  • Key structural properties of surfactants, like hydrophobicity and bonding ability, influence their effectiveness.
  • Surfactants restored α-helix content of the enzyme, stabilizing its structure against phenolic damage.
  • Stronger binding of surfactants in the catalytic tunnel of cellulase compared to phenolics was observed with binding affinities ranging from –20.08 to –29.71 kJ/mol.

Cite This Study

Jiang et al. (2026) studied this question.

synapsesocial.com/papers/69c8c336de0f0f753b39de67https://doi.org/10.1016/j.jobab.2026.100250
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