Demonstrates efficient triazolyl (thio)ureas synthesis in a transition-metal-free manner, suggesting broad applications.
A transition‐metal‐free LiO t Bu‐promoted three‐component reaction for efficient synthesis of the triazolyl (thio)ureas has been reported. This reaction proceeded via the cyclocondensation of nitriles and azides in the presence of a base, followed by the interception of the triazolamine and triazole nitrogen anion intermediate using (thio)carbamoylimidazoles. This method is characterized by being transition‐metal‐free, a broad substrate scope, and mild reaction conditions.
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Wang et al. (2026) studied this question.
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