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March 29, 2026International Journal of Molecular SciencesOpen Access

Serum Eosinophil Cationic Protein (ECP) as a Biomarker for Distinguishing Pediatric Allergic Airway Diseases

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Authors

XCXiaolin ChenSTSiyu TanQLQinxue Lu

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Overview

Cross-sectional analysis evaluates serum ECP for diagnosing pediatric allergic airway diseases, suggesting enhanced diagnostic utility.

Key Points

  • The aim is to assess serum eosinophil cationic protein (ECP) as a biomarker for pediatric allergic airway diseases.
  • Cross-sectional analysis involving children aged 1-17 years
  • Measured serum ECP, total IgE, eosinophil counts, and lung function
  • Used ROC curves to evaluate diagnostic performance
  • Serum ECP levels were significantly higher in allergic asthma, allergic rhinitis, and acute bronchitis compared to healthy controls
  • Marked difference in ECP levels between allergic asthma and allergic rhinitis
  • Combination of ECP and IgE improved diagnostic accuracy for allergic asthma (AUC = 0.9494) and allergic rhinitis (AUC = 0.9501)

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69c8c34bde0f0f753b39dff5https://doi.org/10.3390/ijms27073045
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