Regulation of Primary Hemostasis by Peptides with Neuroprotective Effect

This review summarizes the current understanding of the antiplatelet effects of glyproline peptides (glyprolins) based on literature data and our own experimental studies. The unique properties of these bioregulators are analyzed, allowing them, along with the main neuroprotective effect in the organism, to influence the processes of vascular-platelet hemostasis, which are the main focus. The results of our own studies of PGP, PG, cGP, PGP with the addition of arginine, lysine or leucine, Semax, Selank, KKRRPGP, ACTH(6-9)PGP effects on platelet aggregation activity in normal and metabolic disorders in the organism are presented. Generalized data on the properties of the considered peptides allow us to conclude about the protective antiplatelet effect of glyprolins on the organism and to evaluate the possibility of their use in clinical practice for the prevention and complex therapy of metabolic disorders.