What question did this study set out to answer?

This report aims to highlight the diagnostic challenges and pathophysiology of primary intramedullary spinal cord lymphoma.

Primary intramedullary spinal cord lymphoma presenting as a longitudinal extensive transverse myelitis diagnosed via brain biopsy: a case report

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A case report demonstrates PISCL diagnosis in a 61-year-old male with LETM, indicating the need for careful evaluation.

This report aims to highlight the diagnostic challenges and pathophysiology of primary intramedullary spinal cord lymphoma.
Case report of a 61-year-old male patient
Initial presentation with longitudinally extensive transverse myelitis
Brain biopsy performed after negative skin and bone marrow biopsies
Comprehensive systemic evaluation including brain imaging
Diagnosis of primary intramedullary spinal cord lymphoma confirmed via brain biopsy
Patient had initially nonspecific symptoms mimicking other conditions
Cerebral lesions developed during clinical course
Emphasized the critical role of early diagnosis for better outcomes

Sakiyama et al. (2026) studied this question.

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