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March 29, 2026Psychopathology

Ketamine as a Rapid-Acting Antidepressant: A Scoping Review of Mechanisms and Efficacy in Treatment-Resistant Depression

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Authors

XDXiaoran DingWeifang Medical UniversityYWYaping WuWeifang Medical UniversityJYJuan YangSouthwest University

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Implication

A scoping review summarizes ketamine’s effectiveness and mechanisms in treatment-resistant depression, indicating its rapid action but highlighting safety concerns.

Key Points

  • This review aims to summarize advances in understanding ketamine's role in treating treatment-resistant depression.
  • Conducted a scoping review of recent literature on ketamine.
  • Analyzed mechanisms of action including NMDA receptor antagonism and BDNF expression.
  • Examined neuroimaging studies of ketamine effects on brain connectivity and metabolism.
  • Ketamine shows rapid antidepressant effects in treatment-resistant depression.
  • Mechanisms involve modulation of the glutamatergic system and mTOR pathway activation.
  • Safety concerns and potential dependence require ongoing clinical evaluation.

Cite This Study

Ding et al. (2026) studied this question.

synapsesocial.com/papers/69c8c371de0f0f753b39e367https://doi.org/10.1159/000551413
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Rapid‐acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective2019 · 333 citations
  2. 2Ketamine modulates fronto-striatal circuitry in depressed and healthy individuals2020 · 113 citations
  3. 3Burden of depressive and anxiety disorders in China and its provinces, 1990–2021: findings from the Global Burden of Disease Study 20212025 · 47 citations
  4. 4Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study2015 · 472 citations