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March 29, 2026Diabetes and Vascular Disease ResearchOpen Access

Effect of colchicine for secondary prevention of cardiovascular diseases in individuals with diabetes: A meta-analysis of randomized trials

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Authors

NYNiludi Ranwanee YasaratnaDWDanushi WijekoonJTJean-Claude Tardif

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Overview

Meta-analysis demonstrates colchicine reduces cardiovascular events in individuals with diabetes, indicating a potential preventive strategy.

Key Points

  • This analysis aims to evaluate the effectiveness of colchicine for preventing cardiovascular disease in people with diabetes.
  • Conducted a systematic review of randomized controlled trials on colchicine and cardiovascular outcomes.
  • Analyzed data using a fixed-effects inverse-variance model in RevMan 5.4.
  • Included five RCTs with a total of 2977 participants, equally divided between colchicine and placebo.
  • Colchicine reduced major adverse cardiovascular events (MACE) significantly, HR 0.79 (95% CI 0.67-0.94, p = 0.006).
  • In diabetic participants, the effect was even stronger, HR 0.75 (95% CI 0.67-0.83, p < 0.001).
  • No increase in adverse events, with composites RR 0.81 (95% CI 0.68-0.96; p = 0.02).

Cite This Study

Yasaratna et al. (2026) studied this question.

synapsesocial.com/papers/69c8c3bdde0f0f753b39eafahttps://doi.org/10.1177/14791641261418934
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Colchicine for the secondary prevention of cardiovascular diseases: a cumulative-dose meta-analysis of randomized controlled trials including 31,397 subjects worldwide2025
  2. 2Low dose colchicine for secondary prevention in patients with previous atherosclerotic event: a systematic review and meta-analysis of randomised trials2025
  3. 3Low-Dose Colchicine in Patients With Type 2 Diabetes With Recent Myocardial Infarction in the Colchicine Cardiovascular Outcome Trial (COLCOT): A Systematic Review2025 · 1 citations
  4. 4Meta-Analysis of Randomized Trials: Efficacy and Safety of Colchicine for Secondary Prevention of Cardiovascular Disease2024 · 11 citations
  5. 5Colchicine and cardiovascular events: An updated meta‐analysis of published randomized controlled trials2025 · 5 citations