Why the study?
Is renal tubular resistance the primary driver for loop diuretic resistance in patients with acute heart failure?
Population
Patients with acute heart failure (AHF)
Authors
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Supports tubular resistance as main driver of diuretic resistance in acute HF; hypothesis-generating and requires prospective validation before practice change.
Is renal tubular resistance the primary driver for loop diuretic resistance in patients with acute heart failure?
Renal tubular resistance, rather than reduced diuretic delivery, is the primary driver of loop diuretic resistance in acute heart failure.
Maaten et al. (2017) studied this question.
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