What question did this study set out to answer?

To identify and characterize completely conserved genomic segments across mammalian and vertebrate genomes to understand their distribution and potential biological significance.

May 10, 2004Science

Ultraconserved Elements in the Human Genome

View Full Paper

Ask AI

Bookmark

Authors

GBGill BejeranoStanford University MPMichael PheasantGeisinger Wyoming Valley Medical Center IMIgor V. MakuninUniversité Clermont Auvergne

Discussion

Member takes

Implication

Comparative genomic analysis uncovers hundreds of identical sequences across vertebrate genomes, suggesting essential functional roles in developmental regulation.

Key Points

To identify and characterize completely conserved genomic segments across mammalian and vertebrate genomes to understand their distribution and potential biological significance.
Screened orthologous genomic sequences across human, mouse, and rat genomes for segments displaying 100% identity without insertions or deletions.
Evaluated sequence conservation of identified candidate elements against dog, chicken, and fish genomes.
Mapped genomic coordinates relative to exons, introns, and functional gene classes involved in developmental and regulatory pathways.
Identified 481 genomic segments greater than 200 base pairs and over 5,000 segments exceeding 100 base pairs with absolute sequence identity among humans, mice, and rats.
Observed extensive cross-species conservation among the 481 segments, averaging 99% identity in dogs and 95% in chickens, with significant conservation extending to fish.
Found preferential localization overlapping exons of RNA-processing genes or within introns and flanking regions of genes governing transcription and vertebrate development.

Cite This Study

Bejerano et al. (2004) studied this question.

synapsesocial.com/papers/69c95d03e1a1a5cd25c8cee8 https://doi.org/10.1126/science.1098119

View Full Paper

Ask AI

Bookmark

Implication

Comparative genomic analysis uncovers hundreds of identical sequences across vertebrate genomes, suggesting essential functional roles in developmental regulation.

Ultraconserved Elements in the Human Genome

Discussion

Member takes

Implication

Key Points

Cite This Study

Ultraconserved Elements in the Human Genome

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider