Male sex is associated with a more severe corneal phenotype in individuals with CHED and a Slc4a11<sup>-/-</sup> mouse model of the disease.
Male sex is associated with a more severe corneal phenotype in individuals with CHED and a Slc4a11-/- mouse model of the disease. Increased corneal edema in female Slc4a11-/- mice following gonadectomy suggests ovarian hormones play a protective role in maintaining corneal deturgescence in the setting of loss of SLC4A11 function.
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Zhang et al. (2026) studied this question.
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