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March 30, 2026Current Pharmaceutical Design

The Role of Oxytocin-Driven Synaptic Plasticity in Post-Traumatic Stress Disorder:Mechanisms, Therapeutic Potential, and Future Directions

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Authors

DVDurairaj Ragu VarmanBSBhagavathi Sundaram SivamaruthiFJFairen Angelin Jayakumar

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Overview

This review reveals oxytocin enhances synaptic plasticity and emotional regulation in PTSD, indicating its therapeutic potential and need for personalized approaches.

Key Points

  • This review aims to elucidate the role of oxytocin-driven synaptic plasticity in PTSD and its potential therapeutic implications.
  • Reviewed neurobiological mechanisms related to synaptic plasticity in PTSD
  • Discussed oxytocin signaling and its effects on neuronal plasticity
  • Analyzed preclinical and clinical studies on oxytocin's effects on synaptic function
  • Oxytocin enhances long-term potentiation in the hippocampus
  • Improves emotional regulation by reducing amygdala hyperactivity
  • Highlights the potential for personalized treatment approaches using biomarkers and oxytocin receptor agonists

Cite This Study

Varman et al. (2026) studied this question.

synapsesocial.com/papers/69c9c553f8fdd13afe0bd385https://doi.org/10.2174/0113816128450800260202064712
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neuroplasticity in Post-Traumatic Stress Disorder2025 · 4 citations
  2. 2Oxytocin remodels the brain-heart axis: intranasal treatment rescues PTSD-related deficits in persistent fear memory retention and cardiac autonomic dysfunction2026
  3. 3Oxytocin attenuates fear learning via enhancing somatostatin interneuron–mediated local GABAergic inhibition in the prelimbic cortex2026 · 2 citations
  4. 4Neurobiological Mechanisms Underlying Hippocampal Dysfunction in Post-Traumatic Stress Disorder2026
  5. 5Altered glutamatergic neurotransmission in the development and maintenance of PTSD2026