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March 30, 2026Indian Journal of UrologyOpen Access

Combined gabapentin and solifenacin for symptom management after double-J stent insertion: Randomized controlled trial

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Authors

SSSalman SoltaniMTMahmoud TavakkoliMEMaryam Emadzadeh

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Overview

Randomized trial shows gabapentin and solifenacin enhance symptom control in patients with ureteral stents, indicating better health outcomes.

Key Points

  • To evaluate the effectiveness of gabapentin combined with solifenacin for managing symptoms after double-J stent placement.
  • Randomized controlled trial conducted at a tertiary referral center.
  • 160 adult patients undergoing ureteroscopic lithotripsy with double-J stent placement were randomized into two groups.
  • Intervention group received gabapentin 100 mg and solifenacin 5 mg daily for 2 weeks; control group received solifenacin plus placebo.
  • The intervention group had a mean total Ureteral Stent Symptom Questionnaire score of 75.17, significantly lower than the control group's score of 87.98 (P < 0.001).
  • Significant improvements were seen in urinary symptoms, pain, general health, work performance, with P < 0.05 for all.

Cite This Study

Soltani et al. (2026) studied this question.

synapsesocial.com/papers/69c9c57ff8fdd13afe0bd721https://doi.org/10.4103/iju.iju_166_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relief of double-J stent-related symptoms: a comparison between mirabegron, tamsulosin and solifenacin2024
  2. 2Comparative Efficacy of Tamsulosin and Solifenacin in Managing Double J Stent-Related Symptoms: A Randomized Clinical Study Using the USSQ Tool2025
  3. 3Comparative Approaches in Treating Double-J Stent Syndrome: Monotherapy or Combination Therapy?2024 · 5 citations
  4. 4Double versus standard dose of tamsulosin with solifenacin for management of ureteral stent related symptoms2025
  5. 5Comparison of Efficacy of Combination Therapy (Tamsulosin + Solifenacin) Versus Monotherapy (Tamsulosin) Alone for Double J Stent Related Lower Urinary Tract Symptoms2025