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March 30, 2026Frontiers in ImmunologyOpen Access

Integrated stress response genes as novel biomarkers and therapeutic targets in ankylosing spondylitis: a transcriptomic and Mendelian randomization study

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Authors

SWShuai WangJZJihong ZhuHZHao Zhang

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Overview

Transcriptomic and Mendelian randomization studies identify biomarkers in ankylosing spondylitis, suggesting new treatment options.

Key Points

  • This research aims to identify biomarkers and therapeutic targets related to the integrated stress response in ankylosing spondylitis.
  • Conducted transcriptomic profiling of peripheral blood from ankylosing spondylitis patients.
  • Applied Mendelian randomization to assess causal relationships between ISR genes and AS susceptibility.
  • Performed functional enrichment, immune infiltration, and drug prediction analyses.
  • Validated candidate biomarkers using RT-qPCR in clinical blood samples.
  • Identified downregulation of RORA and FBXO31, and increased expression of MSRB3 in ankylosing spondylitis.
  • Mendelian randomization analysis confirmed the causal role of identified genes in AS risk.
  • Functional enrichment linked ISR genes to olfactory transduction and immune infiltration, particularly involving Th1 cells and keratinocytes.
  • Predicted indirubin and pentoxifylline as potential therapeutic agents.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69ca1210883daed6ee094d28https://doi.org/10.3389/fimmu.2026.1718471
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