Investigative findings indicate an increase in pfdhps A581G mutation frequency in Plasmodium falciparum, highlighting the need for monitoring.
After a decade of seasonal chemoprevention, P. falciparum in southern Senegal carries multiple genetic markers associated with resistance to sulfadoxine-pyrimethamine, including a recent increase in the pfdhps A581G mutation to over 10 %. Although the sulfadoxine-pyrimethamine plus amodiaquine regimen remains clinically effective, the growing frequency of pfdhps A581G mutation warrants close monitoring.
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Diallo et al. (2026) studied this question.
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