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March 30, 2026Naunyn-Schmiedeberg s Archives of PharmacologyOpen Access

Gut microbiota and metabolomic alterations underlying the therapeutic effects of SQJZ capsules in a rat model of chronic renal failure

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Authors

RTRui TanNingxia Medical UniversityTQTianwen QueNingxia Medical UniversityFPFeng PanNingxia Hui Autonomous Region Peoples Hospital

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Implication

Investigates SQJZ Capsules' effects on gut microbiota and renal health in a rat model of chronic renal failure, suggesting therapeutic potential.

Key Points

  • The research aims to evaluate the therapeutic effects of SQJZ Capsules on chronic renal failure and their impact on gut microbiota and metabolomic profiles.
  • Chronic renal failure model was induced in rats via 16 weeks of adenine administration.
  • SQJZ treatment was administered for 35 days, with various doses evaluated.
  • Blood and kidney tissue were analyzed for multiple biomarkers and histopathological changes.
  • Gut microbiota changes were analyzed using 16S rRNA gene sequencing and metabolomic profiling.
  • SQJZ Capsules significantly reduced levels of UA, BUN, Cys C, Scr, TNF-α, and IL-6 compared to the control group (P < 0.001).
  • Histological analysis showed reduced renal fibrosis, inflammatory cell infiltration, and improved intestinal health with SQJZ treatment.
  • Immunohistochemical analysis revealed decreased expression of inflammatory proteins and increased expression of intestinal tight junctions in the high-dose group.
  • 530 differential metabolites were identified, predominantly impacting several metabolic pathways associated with chronic renal failure.

Cite This Study

Tan et al. (2026) studied this question.

synapsesocial.com/papers/69ca12d4883daed6ee095149https://doi.org/10.1007/s00210-026-05210-2
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