Key result
Perioperative antithrombotic therapy is linked to higher surgical complications, including bleeding, after gastrectomy.
Why the study?
Patients with gastric cancer receiving perioperative antiplatelet and/or anticoagulation treatment require careful attention for postoperative surgical complications, including postoperative bleeding after gastrectomy.
Does perioperative antiplatelet and/or anticoagulation therapy increase Grade 2-5 postoperative complications in patients with gastric cancer undergoing gastrectomy?
Cohort (n=2,000)
No
Does perioperative antiplatelet and/or anticoagulation therapy increase Grade 2-5 postoperative complications in patients with gastric cancer undergoing gastrectomy?
Patients with gastric cancer receiving perioperative antiplatelet and/or anticoagulation therapy require careful monitoring for postoperative complications, particularly bleeding, after gastrectomy.
Supports heightened monitoring for bleeding after gastrectomy; leaves open need for prospective trials before practice change.
BACKGROUND/AIM: This study retrospectively evaluated the clinical impact of perioperative antiplatelet and/or anticoagulation therapy (hereafter: antiplatelet/anticoagulation therapy) in more than 2,000 patients with gastric cancer (GC) who underwent gastrectomy. PATIENTS AND METHODS: Patients were selected from the consecutive database of Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Department of Gastric Surgery, between 2005 and 2025. Grade 2-5 postoperative complications (according to the Clavien-Dindo classification) were retrospectively determined from the patients' records. CONCLUSION: Patients with gastric cancer treated with perioperative antiplatelet and/or anticoagulation treatment require careful attention for postoperative surgical complications, including postoperative bleeding after gastrectomy.
No takes yet. Share an insight, caveat, or question.
AOYAMA et al. (2026) conducted a cohort in Gastric cancer (n=2,000). Perioperative antiplatelet and/or anticoagulation therapy vs. No perioperative antiplatelet and/or anticoagulation therapy was evaluated on Grade 2-5 postoperative complications (Clavien-Dindo classification) (p=0.049). Perioperative antiplatelet and/or anticoagulation treatment in patients with gastric cancer undergoing gastrectomy is associated with postoperative surgical complications, including bleeding (p=0.049).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: