Explosive shock wave exposure leads to age-accelerated motor and sensory decline in C. elegans

This is the authors' abstract. We don't add key points for this paper.

Defined shock wave exposure is sufficient to provoke long-term neuronal functional decline in C. elegans, accompanied by structural deterioration and premature neurodegeneration. This tractable model enables lifelong phenotyping and mechanistic dissection of how an acute shock wave insult progresses to chronic neuronal dysfunction, and provides a scalable platform for identifying molecular and pharmacological modifiers that promote resilience.