What question did this study set out to answer?

The aim is to characterize the spectrum of disease and tau pathology in chronic traumatic encephalopathy resulting from repetitive mild traumatic brain injury.

December 2, 2012BrainOpen Access

The spectrum of disease in chronic traumatic encephalopathy

View Full Paper

Ask AI

Bookmark

The aim is to characterize the spectrum of disease and tau pathology in chronic traumatic encephalopathy resulting from repetitive mild traumatic brain injury.
Analyzed post-mortem brain samples from 85 subjects with repetitive mild traumatic brain injury.
Identified and staged hyperphosphorylated tau pathology in the brains.
Compared findings to age- and gender-matched control subjects without repetitive brain injury.
Evidence of chronic traumatic encephalopathy found in 68 subjects, primarily athletes and military veterans.
Tau pathology was progressively staged from I-IV, correlating with symptoms ranging from headache to dementia.
Analyzed correlations between disease stage and athletic exposure, with increased severity and duration of football play.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Analysis reveals a progression of tau pathology in male athletes and veterans with traumatic brain injury, suggesting neurodegenerative correlates.

Cite This Study

McKee et al. (2012) studied this question.

synapsesocial.com/papers/69cab3f5741250c02563991f https://doi.org/10.1093/brain/aws307

View Full Paper

Ask AI

Bookmark

Implication

Analysis reveals a progression of tau pathology in male athletes and veterans with traumatic brain injury, suggesting neurodegenerative correlates.

The spectrum of disease in chronic traumatic encephalopathy

Key Points

Discussion

Implication

Cite This Study

The spectrum of disease in chronic traumatic encephalopathy

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider