Factors influencing the efficacy of nebulized colistimethate sodium in the treatment of severe lung infection caused by carbapenem-resistant gram-negative bacteria

Yu Fu; Ran Li; Genhua Mu; Chuji Cheng; M. Zhao; Yan Gu; Chunmei Zhang; Yang Tao; Yuanyuan Yi; Hao Xu; Dan Li; Genjie Wang; Shukun Chai; Bing Dai; Yanjing Xu; Shuling Deng; Lin Dou; Zhiyu Wang; Yongli Zhang; Zhan Gao; Dong Zhang

doi:10.1016/j.ijid.2026.108588

Key Points

The aim is to identify factors that affect the effectiveness of nebulized colistimethate sodium in severe lung infections.
Analyzed clinical outcomes of nebulized colistimethate sodium in pneumonia treatment.
Identified key factors influencing treatment efficacy.
Evaluated patient responses to therapy.
Confirmed significant clinical benefits from nebulized colistimethate sodium in treating severe pneumonia.
Identified multiple factors that could optimize its clinical use.

Implication

Observational study reveals factors influencing nebulized colistimethate sodium efficacy in severe pneumonia, suggesting improvements in treatment strategies.

Abstract

We confirmed the clinical benefits of a nebulized CMS-based regimen for treating severe pneumonia. Several influential factors were identified, which may help optimize the clinical use of nebulized CMS.

Discussion

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Cite This Study

Fu et al. (2026) studied this question.

synapsesocial.com/papers/69cb63c9e6a8c024954b875e https://doi.org/10.1016/j.ijid.2026.108588

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Factors influencing the efficacy of nebulized colistimethate sodium in the treatment of severe lung infection caused by carbapenem-resistant gram-negative bacteria

Key Points

Implication

Abstract

Discussion

Cite This Study

Factors influencing the efficacy of nebulized colistimethate sodium in the treatment of severe lung infection caused by carbapenem-resistant gram-negative bacteria

Key Points

Implication

Abstract

Discussion

Cite This Study

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