Pilot study finds that higher follicular fluid PFAS concentrations may lower chances of live birth, suggesting environmental influences on fertility.
Higher FF PFAS concentrations were associated with lower odds of achieving live birth, though most 95% confidence intervals included the null. Metabolic pathways enriched for features associated with live birth and features associated with FF PFAS were related to lipid, carbohydrate, vitamin, and cofactor metabolism. Although our sample size was small, our findings align with other studies characterizing environmental exposures in reproductive organs and using the metabolome to assess their impact on fertility.
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Fleury et al. (2026) studied this question.
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