Observational study investigates imaging and procedural outcomes of staged bilateral MRgFUS thalamotomy for essential tremor, suggesting high consistency and safety.
Key Points
This research aims to characterize the imaging and procedural specifics of staged bilateral MRgFUS thalamotomy for essential tremor.
Conducted a retrospective-prospective observational study at a single center
Included consecutive essential tremor patients undergoing staged bilateral MRgFUS thalamotomy
Compared procedural metrics, stereotactic targeting coordinates, and sonication parameters between FUS1 and FUS2
Measured lesion volumes using standardized MRI protocols and semi-automated segmentation
Assessed inter-rater agreement for volumetric measurements
Fifteen patients received staged bilateral MRgFUS thalamotomy with similar metrics between FUS1 and FUS2.
Stereotactic targeting for FUS2 was consistently shifted anteriorly and dorsally compared to FUS1.
No significant differences in lesion volumes at 24 hours and 1 month post-procedure.
Adverse events were mostly mild and transient, with gait disturbances being common and persisting in some cases.
Excellent inter-rater agreement was established for volumetric measurements.