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March 31, 2026Gastrointestinal Endoscopy2 citationsOpen Access

EUS-guided radiofrequency ablation for intraductal papillary mucinous neoplasms with worrisome features : long-term outcomes in non-surgical patients

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JBJulien BarrasDLDiane LorenzoMGMohamed Gasmi

Key Points

  • The study aims to evaluate the long-term outcomes of EUS-RFA for BD-IPMNs in patients who are not candidates for surgery.
  • Analyzed outcomes of patients undergoing EUS-guided radiofrequency ablation
  • Included patients with BD-IPMNs exhibiting worrisome features
  • Provided follow-up to assess durability and safety of the intervention
  • EUS-RFA showed feasibility and safety in treating BD-IPMNs
  • Durable local control was achieved in non-surgical patients
  • Supports further investigation into refined selection criteria for EUS-RFA

Abstract

EUS-RFA is feasible, safe, and provides durable local control of BD-IPMNs with WF/HRS in patients unsuitable for surgery or declining resection. These results support EUS-RFA as a promising therapeutic option in carefully selected patients. Larger prospective studies are needed to refine selection criteria and confirm long-term oncologic benefit.

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Cite This Study

Barras et al. (2026) studied this question.

synapsesocial.com/papers/69cb63c9e6a8c024954b88b3https://doi.org/10.1016/j.gie.2026.03.025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EUS-Guided Radiofrequency Ablation for IPMNs with Worrisome Features: Promise or Illusion?2026
  2. 2Endoscopic ultrasound guided radiofrequency ablation for treatment of pancreatic neuroendocrine tumors: a multicenter prospective study2025
  3. 3Endoscopic ultrasound-guided radiofrequency ablation of pancreatic tumors: Current status and future perspectives2025
  4. 4Methodology Assessment of Endoscopic Ultrasound Radiofrequency Ablation ( <scp>EUS</scp> ‐ <scp>RFA</scp> ) for Pancreatic Neoplasms: Results From an International Survey2026
  5. 5Assessing EUS-guided radiofrequency ablation in unresectable pancreatic ductal adenocarcinoma: a single-center historic cohort study2024 · 17 citations