What question did this study set out to answer?

To investigate how unrecognized donor bloodstream infections impact the outcomes in solid organ transplant recipients.

March 31, 2026Clinical Microbiology and Infection3 citationsOpen Access

Association between Unrecognized Donor Bloodstream Infection and Outcomes in Solid Organ Transplant Recipients: a prospective observational cohort study

ACAndrea ConaIstituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione CCCaterina CuratoloIstituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione PGPaola GiordaniPoliclinico San Matteo Fondazione

Key Points

To investigate how unrecognized donor bloodstream infections impact the outcomes in solid organ transplant recipients.
Prospective observational cohort design
Assessment of donor characteristics and infection status
Monitoring recipient outcomes after transplantation
14% of recipients received organs from donors with bloodstream infections
Only five cases of carbapenem-resistant Enterobacteriaceae drug-drug interactions observed
Indicates that donor infections may lead to adverse recipient outcomes

Abstract

In our cohort, 14% of recipients received organs from donors with BSI but only five CRE DDIs were observed. Receiving organs from donors with unrecognized MDR BSI may adversely affect recipient outcomes; further studies are needed to determine whether newer antimicrobial agents can mitigate this risk.

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