Association between Unrecognized Donor Bloodstream Infection and Outcomes in Solid Organ Transplant Recipients: a prospective observational cohort study

Andrea Cona; Caterina Curatolo; Paola Giordani; Flavia D'Andrea; Diego Bellavia; Maria Campanella; Elena Conoscenti; Sabina Caruso; Giovanni Mulè; Francesco Monaco; Francesca Cardinale; Giuseppina Di Martino; Nicola Cuscino; Floriana Barbera; Daniele Di Carlo; Nicola Coppola; R. Bruno; Giuseppe Nunnari; Salvatore Gruttadauria; Antonio Arcadipane; Angelo Luca; Malgorzata Mikulska; P. Grossi; Alessandra Mularoni

doi:10.1016/j.cmi.2026.03.026

Key Points

To investigate how unrecognized donor bloodstream infections impact the outcomes in solid organ transplant recipients.
Prospective observational cohort design
Assessment of donor characteristics and infection status
Monitoring recipient outcomes after transplantation
14% of recipients received organs from donors with bloodstream infections
Only five cases of carbapenem-resistant Enterobacteriaceae drug-drug interactions observed
Indicates that donor infections may lead to adverse recipient outcomes

Implication

Observational cohort study reveals adverse outcomes linked to donor bloodstream infections in organ recipients, suggesting intervention needs.

Abstract

In our cohort, 14% of recipients received organs from donors with BSI but only five CRE DDIs were observed. Receiving organs from donors with unrecognized MDR BSI may adversely affect recipient outcomes; further studies are needed to determine whether newer antimicrobial agents can mitigate this risk.

Discussion

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Cite This Study

Cona et al. (2026) studied this question.

synapsesocial.com/papers/69cb645fe6a8c024954b8944 https://doi.org/10.1016/j.cmi.2026.03.026

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Association between Unrecognized Donor Bloodstream Infection and Outcomes in Solid Organ Transplant Recipients: a prospective observational cohort study

Key Points

Implication

Abstract

Discussion

Cite This Study

Association between Unrecognized Donor Bloodstream Infection and Outcomes in Solid Organ Transplant Recipients: a prospective observational cohort study

Key Points

Implication

Abstract

Discussion

Cite This Study

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