Interaction between high-sensitivity C-reactive protein and mean platelet volume for 1-year major adverse cardiovascular events in stable coronary artery disease

Figures

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  Fig. 1. Study Flowchart. The diagram illustrates the selection process of the study population. After baseline exclusions, 1503 participants entered follow-up. Participants missing hs-CRP or MPV were excluded, leaving 1,463 patients for the final analysis (71 1-year events). CAD = coronary artery disease; hs-CRP = high-sensitivity C-reactive protein; MPV = mean platelet volume; G1–G4, hs-CRP/MPV phenotype groups defined in Methods.

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  Fig. 2. Association of hs-CRP–MPV joint categories with 1-year MACE. ORs and 95% CIs were estimated using multivariable logistic regression and displayed on a log scale. G1 (hs-CRP ≤ 3 mg/L and MPV < 10.1fL) served as the reference, and ORs for G2–G4 are shown relative to G1. Model 3 was adjusted for age, sex, hypertension, diabetes, and creatinine. Interaction metrics are reported in the figure: multiplicative interaction P = 0.047 and additive interaction RERI = 1.49 (95% CI 0.17–3.14), AP = 0.67 (95% CI 0.10–1.05).

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  Fig. 3. Sensitivity analyses of the association between the co-exposure phenotype (G4) versus the reference group (G1) and 1-year MACE. Squares and horizontal bars represent ORs and 95% CIs on a log scale; the dashed line indicates OR = 1. The main analysis was based on Model 3. Sensitivity analyses included additional adjustment for white blood cell count, statin use, prior myocardial infarction, and number of diseased vessels (complete-case analysis), as well as an alternative phenotype definition (hs-CRP ≥ 2 mg/L) and modeling MPV as a continuous variable within hs-CRP strata. Corresponding ORs, 95% CIs, and P values are shown on the right. WBC = white blood cell; MI = myocardial infarction.