Key result
High mean platelet volume was independently associated with lower aortic distensibility (β = -0.425, P<0.001), diabetes, higher hsCRP, and lower platelet count in patients with stable CAD.
Why the study?
What factors are independently associated with high mean platelet volume in patients with stable coronary artery disease?
Observational (n=411)
What factors are independently associated with high mean platelet volume in patients with stable coronary artery disease?
Effect estimate: β = -0.425 for aortic distensibility
p-value: p=<0.001
In patients with stable coronary artery disease, high mean platelet volume is independently associated with reduced aortic distensibility, diabetes, and chronic inflammation.
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High MPV may mark aortic stiffness in stable CAD; hypothesis-generating for platelet-vascular links, needs prospective validation.
Şahin et al. (2012) conducted an observational in Stable coronary artery disease (n=411). High mean platelet volume (≥9.5 fL) vs. Low mean platelet volume (<9.5 fL) was evaluated on Independent predictors of mean platelet volume (β = -0.425 for aortic distensibility, p=<0.001). High mean platelet volume was independently associated with lower aortic distensibility (β = -0.425, P<0.001), diabetes, higher hsCRP, and lower platelet count in patients with stable CAD.
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