What question did this study set out to answer?

To investigate gallbladder carcinomas with acinar differentiation in the absence of pancreatic lesions.

Primary gallbladder carcinomas showing pancreatic acinar features in the absence of a pancreatic primary

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A series of gallbladder carcinomas exhibit acinar features, indicating a new potential diagnostic variant.

To investigate gallbladder carcinomas with acinar differentiation in the absence of pancreatic lesions.
Identified three gallbladder carcinomas with acinar features from an international cohort.
Reviewed clinical, radiologic, histologic, and immunophenotypic characteristics.
Conducted molecular profiling to identify genetic alterations.
All tumors lacked an associated pancreatic primary on imaging.
Two tumors formed well-demarcated nodules; one showed wall thickening.
One tumor was associated with high-grade dysplasia and BCL10-positive glands.
Heterogeneous alterations included TP53 mutations in two cases.

Yilmaz et al. (2026) studied this question.

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View Full Paper

Ask AI

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Authors

A series of gallbladder carcinomas exhibit acinar features, indicating a new potential diagnostic variant.

To investigate gallbladder carcinomas with acinar differentiation in the absence of pancreatic lesions.
Identified three gallbladder carcinomas with acinar features from an international cohort.
Reviewed clinical, radiologic, histologic, and immunophenotypic characteristics.
Conducted molecular profiling to identify genetic alterations.
All tumors lacked an associated pancreatic primary on imaging.
Two tumors formed well-demarcated nodules; one showed wall thickening.
One tumor was associated with high-grade dysplasia and BCL10-positive glands.
Heterogeneous alterations included TP53 mutations in two cases.

Yilmaz et al. (2026) studied this question.

View Full Paper

Ask AI

Bookmark