February 12, 2025Open Access
View Full PaperArrhythmic Risk Stratification of Carriers of Filamin C Truncating Variants
Structured PICO
Can a 5-variable predictive model estimate the risk of sudden cardiac death or malignant ventricular arrhythmias in phenotype-positive carriers of FLNC truncating variants?
P
Population
Phenotype-positive carriers of Filamin C truncating variants (FLNCtv)
I
Intervention
5-variable predictive model for risk estimation
O
Outcome
Sudden cardiac death (SCD) or malignant ventricular arrhythmia (MVA)hard clinical
A novel 5-variable predictive model can estimate the high risk of sudden cardiac death or malignant ventricular arrhythmias in phenotype-positive carriers of FLNC truncating variants to guide prophylactic ICD implantation.
Abstract
Results suggest that the risk of SCD/MVA in phenotype-positive carriers of FLNCtv was high. A 5-variable predictive model derived from this cohort allows risk estimation and could support clinicians in the shared decision for prophylactic ICD implantation. External cohort validation is warranted.