Effect of Dronedarone on Cardiovascular Events in Atrial Fibrillation
Why the study?
Does dronedarone reduce hospitalization due to cardiovascular events or death in patients with atrial fibrillation?
Population
patients with atrial fibrillation
Authors
Discussion
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Member takes
Key expert perspectives
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
CLChristophe LeclercqProfessor of Cardiology, CHU Rennes, France
“The ATHENA trial shows that dronedarone, a new antiarryhtmic drug similar to amiodarone but with different effects on individual ion channels, reduced the risk of death or hospitalisation for cardiovascular reasons by 36% when compared with placebo. This was in patients without severe heart failure (NYHA class IV) but with paroxysmal or persistent atrial fibrillation or flutter with additional risk factor for death.”
Implication
Supports dronedarone consideration in AF; confirms benefit on CV hospitalization or death.
Key Points
- To evaluate the effect of dronedarone on cardiovascular hospitalization and overall mortality in patients diagnosed with atrial fibrillation.
- Conducted an interventional randomized clinical trial (ClinicalTrials.gov number, NCT00174785).
- Assessed outcomes in patients with atrial fibrillation receiving dronedarone versus standard care/placebo.
- Dronedarone treatment resulted in a qualitative reduction in the combined incidence of cardiovascular-related hospitalization or death.
- Exact event rates, hazard ratios, confidence intervals, and p-values were not reported in the brief abstract.
Structured PICO
Does dronedarone reduce hospitalization due to cardiovascular events or death in patients with atrial fibrillation?
P
Population
patients with atrial fibrillation
I
Intervention
Dronedarone
O
Outcome
hospitalization due to cardiovascular events or deathcomposite
Dronedarone reduces the composite of cardiovascular hospitalization or death in patients with atrial fibrillation.
Cite This Study
Hohnloser et al. (2009) studied this question.