Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials

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The use of composite end points in cardiovascular trials is frequently complicated by large gradients in importance to patients and in magnitude of the effect of treatment across component end points. Higher event rates and larger treatment effects associated with less important components may result in misleading impressions of the impact of treatment.

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Authors

Ignacio Ferreira‐González

Cardiac Imaging

Gaiet Permanyer-Miralda

Antònia Domingo‐Salvany

St. Alexius Heart and Lung Clinic

Journals

BMJ

Actions

Institutions

Mayo Clinic

McMaster University

Western University

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Ferreira‐González et al. (Mon,) studied this question.

synapsesocial.com/papers/69cc63422893a4923719c80d — DOI: https://doi.org/10.1136/bmj.39136.682083.ae

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Combined endpoints: can we use them?· 2002 · 105 citations
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Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

Multiple Analyses in Clinical Trials· 2004 · 20 citations
Lessons Learned From Recent Cardiovascular Clinical Trials: Part II· 2002 · 123 citations
Patients at the center: in our practice, and in our use of language· 2004 · 12 citations
Combined endpoints: can we use them?· 2002 · 105 citations
Intravascular Gamma Radiation for In-Stent Restenosis in Saphenous-Vein Bypass Grafts· 2002 · 5 citations

Problems with use of composite end points in cardiovascular trials: systematic review of randomised controlled trials

Puntos clave

Resumen

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider

Also consider