A systematic review demonstrates the therapeutic potential of Flammulina velutipes in functional foods, suggesting valuable insights for future research.
Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antitumor, immunomodulatory, and gut microbiota-regulating effects. These effects are primarily attributed to bioactive compounds such as polysaccharides, phenolic compounds, and sterols, and are mediated through the modulation of multiple signaling pathways, including NF-κB, MAPK, and PI3K/Akt. Collectively, the available evidence indicates that F. velutipes represents a promising candidate for the development of functional foods and pharmaceutical formulations. This review emphasizes its therapeutic potential and provides valuable insights to guide future medicinal research.
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Özgen et al. (2026) studied this question.
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