Effect of Omega-3 Polyunsaturated Fatty Acids in Management of Oral Mucosal Lesions: A Systematic Review with a Meta-Analysis Focused on Recurrent Aphthous Stomatitis
Systematic review evaluates omega-3 fatty acids for managing oral mucosal lesions, suggesting their potential benefits.
Key Points
The review aims to assess the effectiveness of omega-3 polyunsaturated fatty acids in managing oral mucosal lesions, focusing on recurrent aphthous stomatitis.
Conducted a systematic review registered in PROSPERO (CRD420250655477).
Searched multiple databases, identifying seven eligible studies up to March 2025.
Evaluated various outcomes including the Visual Analog Scale, Ulcer Severity Score, and quality of life.
Included seven studies with 322 participants, showing clinical benefits from omega-3 treatments without side effects.
Pooled analyses suggested pain reduction, ulcer size improvement, and healing time were not statistically significant.
Reported improvements in oral mucositis, mouth opening, tongue protrusion, and overall quality of life.