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Lab tests show 4-MPTC decreases growth and movement in triple-negative breast cancer cells, suggesting new treatment options.
Cell malignant transformation is accompanied by a remodeling of various cell life-support systems, including calcium signaling. Modulation of the calcium signal can significantly sensitize cancer cells, making them more sensitive to anticancer drugs. A search for selective compounds that influence the cell calcium response is a promising area in the development of combination therapies for oncology diseases. The aim of this study was to determine the effect of 4-MPTC on the invasive potential of triple-negative breast cancer cells. 4-MPTC was previously selected as a modulator of the Stim2-dependent calcium entry pathway via a small molecule screening. 4-MPTC was shown to induce a massive calcium release from the intracellular calcium store in the endoplasmic reticulum (ER), blocks store-operated calcium entry, and reduces proliferation and migration activity of MDA-MB-468 triple-negative breast cancer cells.
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Skopin et al. (2026) studied this question.
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