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April 1, 2026Indian Journal of TransplantationOpen Access

Histopathology Analysis, Clinical Profile, and Indications of Graft Nephrectomy: Single-center Study

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Authors

PGPallav GuptaTKTarun KumarVBVinant Bhargava

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Overview

A retrospective analysis examines graft nephrectomy indications and histopathology in kidney transplant recipients, indicating significant findings for clinical practice.

Key Points

  • The aim is to analyze the histopathology and clinical profiles of graft nephrectomy cases and identify key indications.
  • Conducted a ten-year retrospective analysis of graft nephrectomy cases from January 2014 to December 2023.
  • Gathered clinical presentations, immunological profiles, and biochemical parameters from hospital records.
  • Performed detailed histopathological analysis by an experienced renal pathologist, including C4d immunohistochemistry in specimens.
  • Most patients underwent early graft nephrectomy, with 11 cases being ABO incompatible compared to 1 case in late nephrectomy (P = 0.018).
  • Significant association found between acute antibody-mediated rejection and early graft nephrectomy (P = 0.008).
  • Common indications for early graft nephrectomy included vascular thrombosis, showing extensive renal parenchymal necrosis.
  • Common findings in late graft nephrectomy included mixed chronic and acute rejection with interstitial fibrosis and arterial thickening.

Cite This Study

Gupta et al. (2026) studied this question.

synapsesocial.com/papers/69ccb63f16edfba7beb87e4ahttps://doi.org/10.4103/ijot.ijot_24_25
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