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April 1, 2026Molecules0 citationsOpen Access

Integrative Multiomics Analysis of Astragalus membranaceus Extract on Liver Disease

Integrative Multiomics Analysis Reveals the Ameliorative Effects of Astragalus membranaceus Extract on Metabolic Dysfunction-Associated Steatotic Liver Disease

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Authors

JAJiayi AnYLYali LiZZZunhan Zhang

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Overview

Investigation reveals Astragalus membranaceus extract improves metabolic dysfunction in mice, suggesting therapeutic potential.

Key Points

  • The study aims to explore the protective effects of Astragalus membranaceus extract against metabolic dysfunction-associated liver disease.
  • Utilized network pharmacology, hepatic metabolomics, and 16S rRNA sequencing.
  • Analyzed the constituents of Astragalus membranaceus using UPLC-Q-Orbitrap-MS/MS.
  • Performed molecular docking to assess interactions with key hepatic targets.
  • Implemented in vivo experiments in mice fed a high-fat diet.
  • Astragalus membranaceus extract significantly reduced weight gain and hepatic lipid deposition.
  • Lowered serum levels of ALT and AST, indicating liver health.
  • Enhanced SOD activity while reducing oxidative stress markers like MDA.
  • Restored gut microbial diversity by enriching beneficial genera such as Akkermansia.

Cite This Study

An et al. (2026) studied this question.

synapsesocial.com/papers/69ccb63f16edfba7beb87fb8https://doi.org/10.3390/molecules31071120
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