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February 11, 2026PharmaceuticalsOpen Access

Mechanistic Investigation of Astragalus Root in the Management of T2DM-NAFLD Comorbidity: An Integrated Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Study

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Authors

JLJie LiNSNanqi ShaoYGYing Gao

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Overview

Investigates how Astragalus root affects T2DM-NAFLD comorbidity, suggesting potential therapeutic mechanisms.

Key Points

  • The study aims to explore the molecular mechanisms by which Astragalus root alleviates comorbidity of T2DM and NAFLD.
  • Employed network pharmacology to identify bioactive constituents and targets of Astragalus root.
  • Conducted molecular docking and dynamics simulations to assess interactions with key proteins.
  • Performed in vitro experiments to evaluate effects on lipid accumulation and inflammation markers.
  • Identified 25 bioactive constituents and 152 targets related to Astragalus root.
  • PPI network analysis highlighted six core targets including IL-6, AKT1, and TNF.
  • In vitro results showed formononetin reduced lipid accumulation and inflammation, targeting the PI3K/AKT/mTOR pathway.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/698c1cc1267fb587c655f77ehttps://doi.org/10.3390/ph19020289
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Also Consider

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  3. 3Mechanistic Insights into Astragalus Membranaceus for Oral Submucosal Fibrosis: A Network Pharmacology and Experimental Approach2025
  4. 4Computational Modeling of Network Topology and Molecular Dynamics for the Assessment of Therapeutic Potential of the Astragalus Membranaceus-Salvia Miltiorrhiza Drug Pair in the Treatment of Chronic Kidney and Heart Failure2025
  5. 5Study on the Potential Mechanism of Astragaloside IV on Renoprotection in Db/Db Mice via Network Pharmacology and Experimental Validation2026