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September 10, 2025Current Pharmaceutical Design

Mechanistic Insights into Astragalus Membranaceus for Oral Submucosal Fibrosis: A Network Pharmacology and Experimental Approach

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Authors

FZFang ZhangYWYonglian WuCCCheng Chen

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Overview

Network pharmacology identifies key targets in oral submucosal fibrosis, suggesting Astragalus membranaceus as a therapeutic option.

Key Points

  • Astragalus membranaceus injection significantly suppressed fibrosis induced by arecoline in oral fiboblasts.
  • In-vitro experiments demonstrated downregulation of ACTA2 and VEGFA mRNA by ASI at varying concentrations.
  • Network pharmacology revealed 68 common targets linked to Astragalus membranaceus and oral submucosal fibrosis.
  • Molecular docking validated interactions between key targets like EGFR and therapeutic ingredients in the treatment.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c1b19954b1d3bfb60e9006https://doi.org/10.2174/0113816128374420250707120128
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Also Consider

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