Merged in silico-in vitro validations of atenolol and amlodipine besylate with excipient interactions for the design of solid oral dosage forms

Key Points

• This research focuses on understanding the interactions between atenolol, amlodipine, and excipients during preformulation studies.
• Conducted in silico studies using computational methods to predict interactions
• Followed by in vitro assessments to validate predictions
• Analyzed the compatibility of atenolol and amlodipine with different excipients
• Identified significant interactions between drugs and excipients
• Confirmed predictions through in vitro results
• Provided insights into optimal formulations for solid oral dosage forms