Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
April 1, 2026Genel Tıp DergisiOpen Access

From Gene Networks to Repurposed Drugs: A Systems Biomedicine Approach to Endometriosis Management

View Full Paper
Ask AI
Bookmark
Share

Authors

FTFadime Dilşad TaşBABüşra Aydın

Discussion

Loading...

Member takes

Overview

Explores innovative drug therapies for endometriosis, revealing potential new management strategies.

Key Points

  • The aim is to explore new therapeutic strategies for managing endometriosis using systems biomedicine.
  • Analyzed six endometrial tissue datasets from Gene Expression Omnibus (GEO) to identify gene expression patterns.
  • Constructed a biological network of transcription factors, proteins, and microRNAs using Cytoscape.
  • Performed principal component analysis (PCA) to differentiate between healthy and diseased groups.
  • Conducted survival analysis to evaluate the prognostic potential of identified hub genes.
  • Identified 25 hub molecules for in silico drug repositioning from the network analysis.
  • Fluticasone propionate, pyrimethamine, and manumycin A were identified as promising therapeutic candidates.
  • PCA showed ≥80% sensitivity and approximately 50% specificity in distinguishing endometriosis patients from healthy individuals.
  • Survival analysis confirmed the potential of hub genes as diagnostic and prognostic markers.

Cite This Study

Taş et al. (2026) studied this question.

synapsesocial.com/papers/69ccb6ce16edfba7beb88947https://doi.org/10.54005/geneltip.1812858
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment.2025
  2. 2Understanding the Molecular Landscape of Endometriosis: A Bioinformatics Approach to Uncover Signaling Pathways and Hub Genes2024 · 3 citations
  3. 3Exosome-Enriched Hub Gene Networks Identify Diagnostic Biomarkers and Repurposable Therapeutic Targets in Endometriosis2026
  4. 4Integrated Bioinformatic Analysis Reveals the Gene Signatures, Epigenetic Roles, and Regulatory Networks in Endometriosis2024
  5. 5Screening and identification of key biomarkers associated with endometriosis using bioinformatics and next generation sequencing data analysis2024 · 1 citations