This infection model evaluates SARS-CoV-2-related pangolin coronavirus in mice, suggesting applications for vaccine and drug development.
Impact statement SARS‐CoV‐2‐related pangolin coronavirus GX_P2V(short_3UTR) is highly attenuated, but can cause mortality in a specifically designed human ACE2 ‐transgenic mouse model, making it a surrogate model for evaluating the efficacy of vaccines and drugs against SARS‐CoV‐2.
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Wei et al. (2026) studied this question.
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