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January 1, 2026Journal of Cancer Research and TherapeuticsOpen Access

Epstein–Barr virus latent membrane protein-1 expression in nasopharyngeal carcinoma with clinical correlation. A study in North East India

Nito Yepthomi Mejungsangla Longkumer Khrutsozo Kikhi Shirley T. Leivon Clement Momin Senjumroni S. Kikon

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Key Points

This research aims to investigate the expression of LMP-1 in nasopharyngeal carcinoma and its clinical implications.
Analyzed LMP-1 expression using immunohistochemistry in nasopharyngeal carcinoma tissues.
Focused on non-keratinizing histological subtype in a North East India cohort.
Assessed correlation with clinical stages of the carcinoma.
A significant number of NPC cases showed positive LMP-1 expression.
High LMP-1 expression was associated with locally advanced disease stages.
The method provides a practical approach for EBV detection in tissue biopsies, especially in resource-limited areas.

Implication

Study finds correlation between LMP-1 expression and clinical stages in nasopharyngeal carcinoma, suggesting diagnostic value.

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Cite This Study

Yepthomi et al. (2026) studied this question.

synapsesocial.com/papers/69ccb6fd16edfba7beb88ba9 https://doi.org/10.4103/jcrt.jcrt_2091_25

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Diagnostic significance of latent membrane protein 1 (LMP-1), EMA, CD45, CD20 and CD3 in Epstein-Barr Virus-associated Nasopharyngeal Carcinoma2024
2Association of Epstein-Barr virus (EBV) with nasopharyngeal carcinoma: Experience from a North Indian tertiary care hospital2024
3EBV‑LMP1 is involved in vasculogenic mimicry formation via VEGFA/VEGFR1 signaling in nasopharyngeal carcinomapreclinical · 2018 · 39 citations
4Evolutionary analysis of LMP-1 genetic diversity in EBV-associated nasopharyngeal carcinoma: Bioinformatic insights into oncogenic potential2024 · 7 citations
5Association of LMP1 expression and cancer stage of nasopharyngeal carcinoma patients at Dr. Soetomo Regional General Hospital in January 2023 – December 20232025