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April 1, 2026ChildrenOpen Access

Sotatercept in Children with Pulmonary Hypertension—A Narrative Review

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Authors

JSJohanna SchulzVSV. StarkLHLars Harbaum

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Overview

This narrative review evaluates sotatercept's promise for pediatric pulmonary hypertension, suggesting implications for treatment.

Key Points

  • The aim is to evaluate sotatercept's efficacy in treating pulmonary arterial hypertension in children and its relevance based on adult studies.
  • Conducted a narrative synthesis of preclinical studies and randomized controlled trials.
  • Examined pathophysiological and therapeutic differences between adult and pediatric populations.
  • Focused on clinical trial outcomes and safety concerns specific to children.
  • Sotatercept shows efficacy in adults with significant reductions in pulmonary vascular resistance.
  • Improvements noted in right ventricular function and walking distance among adults.
  • Challenges in pediatric application include differences in PAH etiology and growth-related pharmacokinetics.

Cite This Study

Schulz et al. (2026) studied this question.

synapsesocial.com/papers/69ccb6fd16edfba7beb88bb2https://doi.org/10.3390/children13040465
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