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May 3, 2026Frontiers in PediatricsOpen Access

Sotatercept administration in a young infant with severe pulmonary arterial hypertension: A case report

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Authors

ARArjith V. RathakrishnanJTJenna TorgesonABArij Beshish

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Overview

Case report demonstrates clinical improvement in severe pulmonary arterial hypertension in a young infant after sotatercept treatment, indicating promising adjunctive therapy potential.

Key Points

  • This report aims to describe the first use of sotatercept in an infant with severe pulmonary arterial hypertension (PAH) to assess its effects on clinical and echocardiographic parameters.
  • Case report of a young infant with severe treatment-refractory PAH receiving sotatercept.
  • Follow-up over 1 year to monitor clinical and echocardiographic improvements.
  • Sotatercept administration led to significant clinical and echocardiographic improvement in the infant after 1 year.
  • Evidence for enhancing pulmonary vascular remodeling noted, supporting its adjunctive role in pediatric PAH.

Cite This Study

Rathakrishnan et al. (2026) studied this question.

synapsesocial.com/papers/69f6e67c8071d4f1bdfc71f7https://doi.org/10.3389/fped.2026.1806079
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