Abstract Background: Dumping syndrome, historically recognized as a complication of radical gastric resections for peptic ulcer disease, has re-emerged as a critical clinical challenge in the era of bariatric and metabolic surgery. The rapid transit of hyperosmolar nutrients into the small intestine triggers a complex cascade of vasomotor and gastrointestinal symptoms that significantly impair patient quality of life. Objective: This study aims to provide a modern re-evaluation of dumping syndrome by analyzing the shift in its surgical etiology, delineating the neuroendocrine mechanisms of early and late subtypes, and evaluating current diagnostic and therapeutic paradigms within a global and regional context. Methods: A comprehensive review was conducted utilizing major medical databases, international consensus guidelines, and regional epidemiological data from India and Kyrgyzstan. Inclusion criteria focused on literature from 1990 to 2025 detailing pathophysiology, diagnostic accuracy of scoring systems, and pharmacological efficacy. Results: The prevalence of dumping syndrome ranges from 15% to over 75% depending on the surgical procedure, with Roux-en-Y gastric bypass demonstrating the highest risk. Diagnostic criteria have shifted from purely symptom-based indices to physiological provocations such as the modified oral glucose tolerance test. While dietary modification remains the cornerstone of therapy, somatostatin analogues and emerging GLP-1 receptor modulators provide vital support for refractory cases. Conclusion: Effective management requires an integrated approach combining nutritional vigilance, pharmacological precision, and standardized post-operative follow-up. Recognizing the historical transition of this condition is essential for modern surgical practice. Keywords: Dumping Syndrome, Bariatric Surgery, Gastric Bypass, Postprandial Hypoglycemia, Metabolic Surgery, Peptic Ulcer Disease.
Abdumazhit et al. (Mon,) studied this question.