Systematic review demonstrates effective pain relief in oral mucositis, indicating clinical potential for methylene blue.
Methylene blue appears to be a safe and effective option for pain relief in OM, with significant reductions in pain scores observed across studies. Its simplicity, affordability, and favorable safety profile make it a promising adjunctive therapy. Larger randomized trials are needed to validate these findings and explore long-term outcomes.
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Rondelli et al. (2026) studied this question.
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