Research shows placental insufficiency markers improve genetic risk assessment in early-onset fetal growth restriction, suggesting better prenatal counseling.
Placental insufficiency markers, particularly the sFlt-1/PlGF ratio and PlGF level, may enable refined risk stratification of genetic anomalies in cases of isolated early-onset FGR, which could be used to provide individualized prenatal counseling and to optimize the use of WES. Furthermore, combining markers of placental insufficiency, such as UtA-PI and fetal Doppler, may improve risk stratification, potentially defining smaller subgroups with a higher prevalence of genetic anomalies, for which WES may provide greater diagnostic yield.
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Armengol‐Alsina et al. (2026) studied this question.
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