Prospective study reveals strong links between angiogenic biomarkers, Doppler anomalies, and placental pathology in small-for-gestational-age pregnancies, highlighting risks of vascular defects.
In pregnancies with SGA/FGR fetus, mean UtA-PI > 95th centile, abnormal UA Doppler, CPR < 5th centile, PlGF < 100 ng/L and elevated sFlt-1/PlGF ratio were all strongly associated with placental abnormality, particularly MVM.
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Hong et al. (2025) studied this question.
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