This review explores DNA repair pathways influencing chromosomal aberrations, highlighting implications for tumor development.
Double-strand break repair pathways differ in their ability to prevent errors during the joining of broken DNA ends. When DNA breaks on different chromosomes are joined, translocations can form, potentially leading to tumor development. This review discusses the main mechanisms of double-strand break (DSB) repair and the factors that influence the repair process and the formation of chromosomal rearrangements in human cells.
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Lomov et al. (2025) studied this question.
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