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This research aims to investigate the neurobehavioral and cardiotoxic impacts of pyrrolidine-containing cathinones using zebrafish models.

Integrated Assessment of Neurobehavioral and Cardiotoxic Effects of Pyrrolidine-Containing Cathinones in Zebrafish: Structural Determinants of Functional Safety Profiles

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Assesses neurobehavioral and cardiac effects of pyrrolidine-containing cathinones in zebrafish, highlighting their safety profiles.

This research aims to investigate the neurobehavioral and cardiotoxic impacts of pyrrolidine-containing cathinones using zebrafish models.
Employed multiparametric New Approach Methodology (NAM) with zebrafish embryos.
Evaluated nine pyrrolidine-containing cathinones including α-PVP and MDPV.
Assessed locomotor activity and cardiac rhythmicity with high-speed video microscopy.
Applied dynamic pixel analysis to measure endpoints.
Developed a Functional Safety Index to compare neurobehavioral inhibition and conduction impairment.
Most compounds caused concentration-dependent negative chronotropy and locomotor suppression.
3,4-Cl-α-PVP was the most potent inducer of negative chronotropy with an EC50 of 52.6 μM.
4-Cl-α-PVP increased the incidence of 2:1 AV block, indicating pro-arrhythmic liability.
Behavioral profiling showed α-PVP and chlorinated analogs were significant modifiers.
Subtle structural changes influence distinct arrhythmic phenotypes and safety profiles.

Aljabasini et al. (2026) studied this question.

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